It is considered a best practice to backup your Application Enabler configuration file before making changes.
When configuring a line-of-business application, configure all Keyword Types that could potentially be used. Then, configure hotspots to use the Keyword Types that you currently need.
If your solution doesn't require hotspot-specific contexts, then all context actions should be configured during the initial application-enabling configuration. You should only configure contexts at specific hotspots, including the <<Screen>> hotspot, if you need context actions to be available only at those hotspots.