It is recommended that your BizTalk server be installed on a different machine than the one(s) used by the OnBase database server or Application Server. A domain service account is required if the Enterprise Integration Server will be installed on a server that is not the OnBase database server. The Enterprise Integration Server will use this domain service account to communicate with the SQL Server database.
It is recommended to use a domain account for any production environment.
The BizTalk Server setup program automatically configures installed components to use the default accounts. While using the default names simplifies setup and configuration, it is not always possible. For example, there may be multiple BizTalk Server groups within an Active Domain forest. In this situation the account names must be modified to avoid conflicts. If you must change the names, note that BizTalk Server supports only <NetBIOS domain name>\<user> name formats for service accounts and Windows groups.
When configuring Active Directory groups, ensure that the domain service account that will be used by the Enterprise Integration Server, as well as the account of the user currently configuring Active Directory, are part of all Active Directory groups.
After configuring Active Directory groups, proceed to Creating Windows Group and User Accounts in BizTalk Server for instructions on granting both of these accounts SQL Server permissions.