A known issue exists when running any version of McAfee VirusScan with ScriptScan enabled on servers. Running ScriptScan on any OnBase server application will result in decreased performance in OnBase. According to the McAfee Web site, "ScriptScan is not intended or appropriate for server environments and can safely be disabled on servers." To prevent performance issues on servers running McAfee VirusScan, disable ScriptScan on these servers.
For more information on other recommended settings for servers, refer to the documentation provided by the vendor of your antivirus software.