If you are upgrading from a version of OnBase prior to OnBase 16 and you are using Epic Hyperspace, you must update the Scan Acquisition Server ProgID in Epic. If the Scan Acquisition Server ProgID is not updated when OnBase is upgraded, then integrated scanning with Epic Hyperspace will not work.
Beginning in OnBase 16, the Scan Acquisition Server ProgID must reflect the Epic Hyperspace version for Epic August 2018 and later, as shown: OBEpicScanWrp85.OBEpicScanWrapper.