This setting specifies whether general registry settings (i.e., thumbnail settings) should be read from the HKEY_CURRENT_USER hive or the HKEY_LOCAL_MACHINE hive.
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Set to 0 if you want general settings to be stored and read from HKEY_LOCAL_MACHINE. This is the default setting.
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Set it to 1 if you want general settings to be stored and read from HKEY_CURRENT_USER.
For more information, see Choosing Where Registry Settings Are Stored.