When antivirus software scans the virtual directory of a web server application like OnBase Patient Window, the scan may cause the application to restart. As a result, users currently logged on to the application lose their sessions, and the application becomes unresponsive. For OnBase applications, the OnBase Event Log records the “Application End” and “Application Start” events, which are followed by a series of errors. The Diagnostics Console logs the message, “Failed to get session for session id.”
The recommended solution is to disable antivirus software from scanning the server's virtual directories as well as the ASP.NET Temporary Files located in C:\WINDOWS\Microsoft.NET\Framework\v4.0.30319\Temporary ASP.NET Files.
The Microsoft Knowledge Base describes this issue in greater detail. For more information, refer to the following articles:
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http://support.microsoft.com/kb/821438
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http://support.microsoft.com/kb/312592/en-us?spid=8940&sid=global
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http://support.microsoft.com/kb/316148/EN-US/